Manufacturer: Virbac (Australia) Pty Limited Registered Name Virbac Canimax Palatable Allwormer for [Small, Medium, Large] Dogs Composition Canimax for Small Dogs. Abamectin 0.05 mg, praziquantel 25 mg, oxibendazole 112.5 mg. Medium Dogs. Abamectin 0.1 mg, praziquantel 50 mg, oxibendazole 225 mg. Large Dogs. Abamectin 0.2 mg, praziquantel 100 mg, oxibendazole 450 mg. Actions Anthelmintic; abamectin blocks the transmission of nerve impulses within heartworm larvae, leading to their paralysis and eventual death. Abamectin blocks these nerve impulses by stimulating the release of a neurotransmitter gamma-aminobutyric acid (GABA), and by binding to glutamate gated chloride channels in the nerve and muscle tissues of the heartworm larvae. Oxibendazole disrupts parasite energy metabolism by binding to tubulin, a protein required for the uptake of nutrients and other functions in the parasite. Benzimidazoles also produce many changes in susceptible nematodes, e.g. inhibition of mitochondrial fumerate reductase, reduced glucose transport and uncoupling of oxidative phosphorylation. Praziquantel disrupts the integument of the tapeworm, exposing it to damage from digestive enzymes in the gut and to attack by the dog's immune system. Praziquantel also interferes with muscles in the tapeworm scolex, causing a loss of attachment to the bowel wall. Indications Prevention of heartworm disease and treatment of roundworm, hookworm, whipworm and tapeworm (including hydatid tapeworm) in dogs. Precautions Safety directions. Harmful if swallowed. Wash hands after use. First aid. If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126. Disposal. Dispose of empty container by wrapping with paper and putting in garbage. Dosage and Administration Dose. Canimax for Small Dogs: 1 tablet/5 kg bodyweight. Medium Dogs: 1 tablet/10 kg. Large Dogs: 1 tablet/20 kg. Give every six weeks. Safe for use in pregnant bitches. Puppies. Commence treatment at 6 to 8 weeks of age and re-treat every six weeks. Adults dogs. Re-treatment is required every six weeks.
