Manufacturer: Novartis Animal Health Australasia Pty Limited Composition Milbemax Tablets for Small Cats. Milbemycin oxime 4 mg, praziquantel 10 mg. Milbemax Tablets for Cats. Milbemycin oxime 16 mg, praziquantel 40 mg. Actions Milbemycin oxime is believed to interfere with the transmission of nerve messages in roundworms, hookworms and heartworm by binding to receptor sites on the cell membrane's glutamate gated chloride channels, leading to hyperpolarisation and elimination of nerve signal transmission. Praziquantel causes influx of Ca2+ at receptors on the body surface of tapeworms. This leads to membrane depolarisation and almost instantaneous contraction of the musculature (tetany), rapid vacuolisation of the syncytial tegument and subsequent tegumental disintegration (blebbing), resulting in easier expulsion from the gastrointestinal tract or death of the tapeworm. Use for the treatment and control of adult and immature roundworm (Toxocara cati, Toxascaris leonina), adult and immature hookworm (Ancylostoma tubaeforme) and tapeworm (Dipylidium caninum, Taenia sp.) and prevention of heartworm (Dirofilaria immitis) in cats over 6 weeks of age and 500 g in bodyweight. Precautions Cats should be examined for existing heartworm infection prior to starting treatment with Milbemax as a heartworm preventative. Consideration should be given to treating infected cats to remove adult heartworm if present. This formulation is not suitable for dogs. First aid. If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126. If in eyes, hold eyes open, flood with water for at least 15 minutes and see a doctor. Dosage and Administration Milbemax tablets should be given by mouth at a minimum dose rate of milbemycin oxime 2 mg/kg and praziquantel 5 mg/kg bodyweight. Cats should be dosed according to bodyweight as follows. Cats 0.5 to 1 kg bodyweight. Give 1/2 Milbemax tablet for Small Cats (pink). 1 to 2 kg. Give 1 Milbemax tablet for Small Cats (pink). 2 to 4 kg. Give 1/2 Milbemax tablet for Cats (dark red). 4 to 8 kg. Give 1 Milbemax tablet for Cats (dark red). 8 to 12 kg. Give 1 1/2 Milbemax tablets for Cats (dark red). Do not use the Tablets for Small Cats in cats less than 6 weeks of age and/or weighing less than 0.5 kg. Do not use the Tablets for Cats in cats weighing less than 2 kg. Can be used in breeding animals including toms and pregnant and lactating queens. Control of gastrointestinal worms. Treat at 6, 8 and 12 weeks of age then every three months. Lactating queens should be treated at the same time as their kittens. Adult cats should be treated every three months. Heartworm prevention. Administer every month, preferably on the same date. If monthly interval is missed, administer immediately and resume normal monthly dosing schedule.
